Nociplastic pain is best described as central sensitization.

• A. True
• B. False
• C. Nociceptive Pain
• D. Neuropathic Pain

Answer: (A)

Nociplastic pain reflects altered processing of pain in the central nervous system, leading to central sensitization. This means the CNS becomes more excitable and amplifies pain signaling, producing heightened pain responses (like allodynia and hyperalgesia) even when there isn’t clear ongoing tissue damage or a somatosensory nerve lesion. That’s why nociplastic pain is best described as central sensitization.

Nociceptive pain, in contrast, comes from actual tissue injury that activates nociceptors, and neuropathic pain arises from a lesion or disease of the somatosensory pathways. So the statement is true.